Double staining: Cilia labelling could be observed for IFT57 (Red, CHE-13) in the ciliated sensory PHA/PHB neurons.Marker labelled in red is a ciliary marker. A new ciliary gene (Green) co-localized with IFT57 (Red). Ciliopathies are caused by defects in the cilia structure or function. Cilia are highly conserved microtubule-based organelles. For this reason, we employ the nematode C. elegans to characterise the roles of ciliopathy-associated genes. We have been using CRISPR/Cas9 gene editing technology to model human diseases in C. elegans . With the help of CRISPR, we have recently generated our first CRISPR mutant and are currently performing functional analysis of a novel ciliary gene.